Kaito Hioki

Kaito Hioki – NIH Trainee 2022-2024

Research progress:

I am a PhD student in the Pobezinsky lab, studying mechanisms of T cell-based immunity and classification of rare T cell subsets. During the last two years I worked on multiple different projects that resulted in two first author publications. For my first paper, I analyzed RNAseq data for transgenic T cells overexpressing the Let-7 microRNA, which have superior anti-tumor capacity compared to wild type T cells. In my second paper, I investigated a phenomenon of intercellular transfer of cytoplasmic material from tumor cells to immune cells in mice, and inspected the potentially detrimental impact on the immune system. Over the last year and a half, I worked on a follow-up project to investigate whether similar phenomena occur in healthy tissue, in particular with immune cells in the intestinal epithelium. This project split to a two projects after we discovered a novel population of cells by scRNAseq; however, several papers were published before we could complete our analyses to characterize these cells. This subproject is currently in writing for a small publication. 


Wells, A.C., Hioki, K.A., Angelou, C.C. Lynch, A.C., Liang, X., Ryan, D.J., Thesmar, I., Zhanybekova, S., Zuklys, S., Ullom, J., Cheong, A., Mager, J., Hollander, G.A., Pobezinskaya, E.L., and Pobezinsky, L.A. Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation. Nat Commun14, 5585 (2023). https://www.nature.com/articles/s41467-023-40959-7  

Hioki, K.A., Ryan, D.J., Thesmar, I., Lynch, A.C., Pobezinsky, L.A. and Pobezinskaya, E.L. The mosquito effect: regulatory and effector T cells acquire cytoplasmic material from tumor cells through intercellular transfer. Front. Immunol. 14:1272918 (2023). https://doi.org/10.3389/fimmu.2023.1272918 

He, X. D., Phillips, S., Hioki, K.A., Majhi, P. D., Babbitt, C., Tremblay, K. D., Pobezinsky, L. A., & Mager, J. (2024). TATA-binding associated factors have distinct roles during early mammalian development. Developmental Biology, 511, 53–62. https://doi.org/10.1016/j.ydbio.2024.04.002